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Analysis of Transcriptional Regulatory Regions

James W. Fickett(1), Artemis Hatzigeorgiou(2), Wyeth Wasserman(1)

(1) SmithKline Beecham Pharmaceuticals (2) Synaptic Ltd.

Determination of gene expression patterns is of great current interest, particularly for assignment of tentative functional roles to newly discovered genes. Computational methods hold the promise of aiding in this determination, though as yet relatively few practical results have been shown. An overview of progress in this area will be given, including benchmark results on promoter recognition algorithms and development of an algorithm to recognize skeletal muscle-specific regulatory regions.

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